Make age just 
a number.

Product line includes: Tru Niagen^® Pro 300mg, Tru Niagen^® Pro 500mg, and Tru Niagen^® Stick Packs

While many factors contribute to aging, scientists believe the depletion of a key cellular resource called nicotinamide adenine dinucleotide (NAD+) is one significant factor^1-4. NAD+ is the critical catalyst that powers energy metabolism. It allows your mitochondria to convert the food you eat into the energy your body needs to sustain its healthy function.
Between the ages of 40 and 60, we can lose up to 50% of our NAD+⁵. When NAD+ levels are low, cells become less efficient at generating the energy needed to maintain health as we age.

Our bodies use NAD+ every day for basic functions like eating, breathing, and sleeping, and for complex functions such as cellular repair. Your experience with increased NAD+ levels may vary depending on your age, health status, weight, and activity level. The most commonly noticed changes reported by Tru Niagen^® users include improvements in energy levels and an enhanced sense of overall well-being.*

The largest published human trial of Niagen^® confirmed that even though we know Tru Niagen^® starts working to increase NAD+ as soon as you

What To Expect

Tru Niagen^® Pro is daily cellular energy support designed to help maintain your health, longer. Its key ingredient, Niagen^® nicotinamide riboside, often referred to as ‘NR’, is a unique form of vitamin B3 clinically proven to safely boost NAD+ to support your cells’ ability to generate energy.*
 
Your healthcare provider may have recommended Tru Niagen^® Pro to provide you with cellular care to help you Age Better^® and live better.*
 
New research on NR is constantly being published. Ask your healthcare provider to share the latest on the benefits of boosting NAD+ to support cellular health.

What is Tru Niagen^® Pro?

OUR REVIEWS

Read what people are saying about our super nutrient and the benefits of higher NAD⁺ levels.

Pro, you know you are getting the only clinically proven and FDA-notified form of NR.

Rigorous testing using internationally accepted safety protocols has confirmed the safety of Niagen^® NR. Nine published clinical trials demonstrate that NR safely and effectively increases NAD+ in humans^6-14. Niagen^® NR has been successfully reviewed twice under the Food and Drug Administration’s (FDA) New Dietary Ingredient (NDI) notification program for up to 300mg. It has also been successfully notified to the FDA as generally recognized as safe (GRAS) at levels up to 180mg/day and has been reviewed by an expert panel for self-affirmed (GRAS) for up to 500mg in dietary supplements provided by HCPs.

A Safe, Evidence-Based Approach To Ongoing Cellular Health

take it, the study showed that it takes about two weeks to fully increase NAD+ levels to a new elevated level. With continued use, participants experienced a sustained 40% to 50% increase in NAD+ levels by the end of the eight-week study⁹

Whatever your experience, you can feel confident that the science shows that NR is hard at work, boosting NAD+ at the cellular level.* The longer you take Tru Niagen^® Pro, the more opportunities you'll have to reap the benefits without adverse side effects.

References

Ask your healthcare professional about 
Tru Niagen^® PRO today.

© 2021 ChromaDex, Inc. All Rights Reserved.

Terms of Use  |  Privacy Policy  |    Accessibility

OUR REVIEWS

Read what people are saying about our super nutrient and the benefits of higher NAD levels.

Ask your healthcare professional about 
Tru Niagen^® today.

© 2021 ChromaDex, Inc. 
All Rights Reserved.

Terms of Use  |  Privacy Policy
 Accessibility

Tru Niagen^® Pro is available in 300mg and 500mg dose options.

Tru Niagen^® Pro offers you the highest dose of Niagen^® NR per capsule (500mg) and is available exclusively through your healthcare provider.

Tru Niagen^® does not contain caffeine, animal byproducts, artificial flavors or colors and is formulated without nuts or gluten.

What's in the bottle?

Take as directed by your healthcare provider, at the same time each day, with or without food.

How to take 
Tru Niagen^® Pro?

Niagen^® has also been reviewed and accepted by three of the most rigorous regulatory bodies in the world—US Food and Drug Administration (FDA), European Commission, and Therapeutic Goods Administration of Australia, and has been authorized for sale in finished products by Health Canada.

Its key ingredient has now been studied in more than 100 preclinical investigations and has multiple published human trials, with more than 40 ongoing.

Tru Niagen^® products bearing the NSF Certified for Sport^® seal undergo additional testing from NSF International, helping everyone from professional athletes to everyday workout warriors verify they are making a safe supplement choice.

Tru Niagen^® increases NAD+ by 40–50% after 8 weeks

[1] E.F. Fang, S. Lautrup, Y. Hou, T.G. Demarest, D.L. Croteau, M.P. Mattson, V.A. Bohr, NAD+ in Aging: Molecular Mechanisms and Translational Implications, Trends Mol Med. 23 (2017) 899–916. https://doi.org/10.1016/j.molmed.2017.08.001.
[2] L. Rajman, K. Chwalek, D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence, Cell Metab. 27 (2018) 529–547. https://doi.org/10.1016/j.cmet.2018.02.011.
[3] E. Verdin, NAD+ in aging, metabolism, and neurodegeneration, Science. 350 (2015) 1208–1213. https://doi.org/10.1126/science.aac4854.
[4] J. Yoshino, J.A. Baur, S. Imai, NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR, Cell Metab. 27 (2017) 513–528. https://doi.org/10.1016/j.cmet.2017.11.002.
[5] H. Massudi, R. Grant, N. Braidy, J. Guest, B. Farnsworth, G.J. Guillemin, Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue, Plos One. 7 (2012) e42357. https://doi.org/10.1371/journal.pone.0042357.
[6] S.A.J. Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud, C. Brenner, Nicotinamide riboside is uniquely and orally bioavailable in mice and humans, Nat Commun. 7 (2016) 12948. https://doi.org/10.1038/ncomms12948.
[7] S.E. Airhart, L.M. Shireman, L.J. Risler, G.D. Anderson, G.A.N. Gowda, D. Raftery, R. Tian, D.D. Shen, K.D. O’Brien, An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers, Plos One. 12 (2017) e0186459. https://doi.org/10.1371/journal.pone.0186459.
[8] C.R. Martens, B.A. Denman, M.R. Mazzo, M.L. Armstrong, N. Reisdorph, M.B. McQueen, M. Chonchol, D.R. Seals, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults, Nat Commun. 9 (2018) 1286. https://doi.org/10.1038/s41467-018-03421-7.
[9] D. Conze, C. Brenner, C.L. Kruger, Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults, Sci Rep-Uk. 9 (2019) 9772. https://doi.org/10.1038/s41598-019-46120-z.
[10] Y.S. Elhassan, K. Kluckova, R.S. Fletcher, M.S. Schmidt, A. Garten, C.L. Doig, D.M. Cartwright, L. Oakey, C.V. Burley, N. Jenkinson, M. Wilson, S.J.E. Lucas, I. Akerman, A. Seabright, Y.-C. Lai, D.A. Tennant, P. Nightingale, G.A. Wallis, K.N. Manolopoulos, C. Brenner, A. Philp, G.G. Lavery, Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures, Cell Reports. 28 (2019) 1717-1728.e6. https://doi.org/10.1016/j.celrep.2019.07.043.
[11] B. Zhou, D.D. Wang, Y. Qiu, S. Airhart, Y. Liu, A. Stempien-Otero, K.D. O’Brien, R. Tian., Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure, J Clin Invest. 130 (2020) 6054–6063. https://doi.org/10.1172/jci138538.
[12] C. Zhang, E. Bjornson, M. Arif, A. Tebani, A. Lovric, R. Benfeitas, M. Ozcan, K. Juszczak, W. Kim, J.T. Kim, G. Bidkhori, M. Stahlman, P.O. Bergh, M. Adiels, H. Turkez, M.R. Taskinen, J. Bosley, H.U. Marschall, J. Nielsen, M. Uhlen, J. Boren, A. Mardinoglu, The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease, Mol Syst Biol. 16 (2020) e9495. https://doi.org/10.15252/msb.209495.
[13] C.M.E. Remie, K.H.M. Roumans, M.P.B. Moonen, N.J. Connell, B. Havekes, J. Mevenkamp, L. Lindeboom, V.H.W. de Wit, T. van de Weijer, S.A.B.M. Aarts, E. Lutgens, B.V. Schomakers, H.L. Elfrink, R. Zapata-Pérez, R.H. Houtkooper, J. Auwerx, J. Hoeks, V.B. Schrauwen-Hinderling, E. Phielix, P. Schrauwen, Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans, Am J Clin Nutrition. 112 (2020) 413–426. https://doi.org/10.1093/ajcn/nqaa072.
[14] O.L. Dollerup, B. Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stødkilde-Jørgensen, N. Møller, C. Brenner, J.T. Treebak, N. Jessen, A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects, Am J Clin Nutrition. 108 (2018) 343–353. https://doi.org/10.1093/ajcn/nqy132.
[15] C. Canto, R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, P. Cettour-Rose, K. Gademann, C. Rinsch, K. Schoonjans, A.A. Sauve, J. Auwerx, The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity, Cell Metab. 15 (2012) 838–47. https://doi.org/10.1016/j.cmet.2012.04.022.
[16] H. Zhang, D. Ryu, Y. Wu, K. Gariani, X. Wang, P. Luan, D. D’Amico, E.R. Ropelle, M.P. Lutolf, R. Aebersold, K. Schoonjans, K.J. Menzies, J. Auwerx, NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice, Science. 352 (2016) 1436–1443. https://doi.org/10.1126/science.aaf2693.
[17] K. Gariani, K.J. Menzies, D. Ryu, C.J. Wegner, X. Wang, E.R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y.K. Park, A. Piersigilli, T.X. Pham, Y. Yang, C.S. Ku, S.I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A.A. Sauve, J.Y. Lee, J. Auwerx, Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice, Hepatology. 63 (2016) 1190–204. https://doi.org/10.1002/hep.28245.
[18] L. Mouchiroud, R.H. Houtkooper, N. Moullan, E. Katsyuba, D. Ryu, C. Cantó, A. Mottis, Y.-S. Jo, M. Viswanathan, K. Schoonjans, L. Guarente, J. Auwerx, The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling, Cell. 154 (2013) 430–441. https://doi.org/10.1016/j.cell.2013.06.016.
[19] S. Wang, T. Wan, M. Ye, Y. Qiu, L. Pei, R. Jiang, N. Pang, Y. Huang, B. Liang, W. Ling, X. Lin, Z. Zhang, L. Yang, Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway, Redox Biol. 17 (2018) 89–98. https://doi.org/10.1016/j.redox.2018.04.006.

Make age 
just a number.

While many factors contribute to aging, scientists believe the depletion of a key cellular resource called nicotinamide adenine dinucleotide (NAD+) is one significant factor^1-4. 

NAD+ is the critical catalyst that powers energy metabolism. It allows your mitochondria to convert the food you eat into the energy your body needs to sustain its healthy function.

Between the ages of 40 and 60, we can lose up to 50% of our NAD+⁵. When NAD+ levels are low, cells become less efficient at generating the energy needed to maintain health as we age.

Tru Niagen^® Pro is daily cellular energy support designed to help maintain your health, longer. Its key ingredient, Niagen^® nicotinamide riboside, often referred to as ‘NR’, is a unique form of vitamin B3 clinically proven to safely boost NAD+ to support your cells’ ability to generate energy.*
 
Your healthcare provider may have recommended Tru Niagen^® Pro to provide you with cellular care to help you Age Better^® and live better.*
 
New research on NR is constantly being published. Ask your healthcare provider to share the latest on the benefits of boosting NAD+ to support cellular health.

What is 
Tru Niagen^® Pro?

Tru Niagen^® Pro is available in 300mg and 500mg dose options.

Tru Niagen^® Pro offers you the highest dose of Niagen^® NR per capsule (500mg) and is available exclusively through your healthcare provider. Tru Niagen^® does not contain caffeine, animal byproducts, artificial flavors or colors, and is formulated without nuts or gluten.

What's in the bottle?

Take as directed by your healthcare provider, at the same time each day, with or without food.  

How to take 
Tru Niagen^® Pro?

Product line includes: Tru Niagen^® Pro 300mg, Tru Niagen^® Pro 500mg, and Tru Niagen^® Stick Packs

Our bodies use NAD+ every day for basic functions like eating, breathing, and sleeping, and for complex functions such as cellular repair. Your experience with increased NAD+ levels may vary depending on your age, health status, weight, and activity level. The most commonly noticed changes reported by Tru Niagen^® users include improvements in energy levels and an enhanced sense of overall well-being.*
 
The largest published human trial of Niagen^® confirmed that even though we know Tru Niagen^® starts working to increase NAD+ as soon as you take it, the study showed that it takes about two weeks to fully increase NAD+ levels to a new elevated level. 
With continued use, participants experienced a sustained 40% to 50% increase in NAD+ levels by the end of the eight-week study⁹.
 
Whatever your experience, you can feel confident that the science shows that NR is hard at work, boosting NAD+ at the cellular level.* The longer you take Tru Niagen^® Pro, the more opportunities you’ll have to reap the benefits without adverse 
side effects.

What To Expect

Tru Niagen^® increases NAD⁺ by 40–50% after 8 weeks

When you take Tru Niagen^® Pro, you know you are getting the only clinically proven and FDA-notified form of NR.

Rigorous testing using internationally accepted safety protocols has confirmed the safety of Niagen^® NR. Nine published clinical trials demonstrate that NR safely and effectively increases NAD+ in humans^6–14. Niagen^® NR has been successfully reviewed twice under the Food and Drug Administration’s (FDA) New Dietary Ingredient (NDI) notification program for up to 300mg. It has also been successfully notified to the FDA as generally recognized as safe (GRAS) at levels up to 180mg/day and has been reviewed by an expert panel for self-affirmed (GRAS) for up to 500mg in dietary supplements provided by HCPs. Niagen^® has also been reviewed and accepted by three of the most rigorous regulatory bodies in the world—US Food and Drug Administration (FDA), European Commission, and Therapeutic Goods Administration of Australia, and has been authorized for sale in finished products by Health Canada.
 
Its key ingredient has now been studied in more than 100 preclinical investigations and has multiple published human trials, with more than 40 ongoing.

Tru Niagen^® products bearing the NSF Certified for Sport^® seal undergo additional testing from NSF International, helping everyone from professional athletes to everyday workout warriors verify they are making a safe supplement choice.

A Safe, Evidence-Based Approach To Ongoing Cellular Health

References

[ 1 ] Fang, E.F., S. Lautrup, Y. Hou, T.G. Demarest, D.L. Croteau, M.P. Mattson, and V.A. Bohr, NAD(+) in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med, 2017. 23(10): p. 899-916. [ 2 ] Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD+-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547. [ 3 ] Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13. [ 4 ] Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528. [ 5 ] Massudi, H., R. Grant, N. Braidy, J. Guest, B. Farnsworth, and G.J. Guillemin, Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357. [ 6 ] Trammell, S.A., M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud, and C. Brenner, Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948. [ 7 ] Airhart, S.E., L.M. Shireman, L.J. Risler, G.D. Anderson, G.A. Nagana Gowda, D. Raftery, R. Tian, D.D. Shen, and K.D. O’Brien, An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459. [ 8 ] Martens, C.R., B.A. Denman, M.R. Mazzo, M.L. Armstrong, N. Reisdorph, M.B. McQueen, M. Chonchol, and D.R. Seals, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286. [ 9 ] Conze, D., C. Brenner, and C.L. Kruger, Safety and Metabolism of Long-term Administration of Niagen® (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep, 2019. 9(1): p. 9772. [ 10 ] Canto, C., R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, P. Cettour-Rose, K. Gademann, C. Rinsch, K. Schoonjans, A.A. Sauve, and J. Auwerx, The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47. [ 1 1 ] Zhang, H., D. Ryu, Y. Wu, K. Gariani, X. Wang, P. Luan, D. D’Amico, E.R. Ropelle, M.P. Lutolf, R. Aebersold, K. Schoonjans, K.J. Menzies, and J. Auwerx, NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 2016. 352(6292): p. 1436-43. [ 12 ] Gariani, K., K.J. Menzies, D. Ryu, C.J. Wegner, X. Wang, E.R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y.K. Park, A. Piersigilli, T.X. Pham, Y. Yang, C.S. Ku, S.I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A.A. Sauve, J.Y. Lee, and J. Auwerx, Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204. [ 13 ] Mouchiroud, L., R.H. Houtkooper, N. Moullan, E. Katsyuba, D. Ryu, C. Canto, A. Mottis, Y.S. Jo, M. Viswanathan, K. Schoonjans, L. Guarente, and J. Auwerx, The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell, 2013. 154(2): p. 430-41. [ 14 ] Wang, S., T. Wan, M. Ye, Y. Qiu, L. Pei, R. Jiang, N. Pang, Y. Huang, B. Liang, W. Ling, X. Lin, Z. Zhang, and L. Yang, Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98. [ 15 ] Dollerup, O.L., B. Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stodkilde-Jorgensen, N. Moller, C. Brenner, J.T. Treebak, and N. Jessen, A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.l