Product line includes: Tru Niagen® Pro 300mg, Tru Niagen® Pro 500mg, and Tru Niagen® Stick Packs
What To Expect
What is Tru Niagen® Pro?
A Safe, Evidence-Based Approach To Ongoing Cellular Health
Ask your healthcare professional about
Tru Niagen® PRO today.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
© 2021 ChromaDex, Inc. All Rights Reserved.
44 feeling like 25
After months of TRU NIAGEN I have more stamina and feel great....I also have been exercising more and losing weight, I feel this is an effective vitamin and will continue to use it long term. Much thanks.
At this time, I cannot identify any health benefits that I have experienced. However, I am encouraged to continue taking this product, based on the scientific research regarding the role of NAD+ in human health. Plus, laboratory analysis has shown that TRU NIAGEN's product is of high quality and contains the specified ingredients in the quantities shown in the "list of ingredients" displayed on the container.
A Supplement Based on Solid Scientific Studies
It's All Relative
More important than what number you write down on the form is how you are aging, the way you feel, the energy you bring to each day, the time it takes to heal after a physical challenge, the resilience you display to stresses in life. TRU NIAGEN doesn't stop the clock, but it certainly has improved the quality of my years.
44 feeling like 25
After months of TRU NIAGEN I have more stamina and feel great....I also have been exercising more and losing weight, I feel this is an effective vitamin and will continue to use it long term. Much thanks.
At this time, I cannot identify any health benefits that I have experienced. However, I am encouraged to continue taking this product, based on the scientific research regarding the role of NAD+ in human health. Plus, laboratory analysis has shown that TRU NIAGEN's product is of high quality and contains the specified ingredients in the quantities shown in the "list of ingredients" displayed on the container.
A Supplement Based on Solid Scientific Studies
It's All Relative
More important than what number you write down on the form is how you are aging, the way you feel, the energy you bring to each day, the time it takes to heal after a physical challenge, the resilience you display to stresses in life. TRU NIAGEN doesn't stop the clock, but it certainly has improved the quality of my years.
Ask your healthcare professional about
Tru Niagen® today.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
© 2021 ChromaDex, Inc.
All Rights Reserved.
What's in the bottle?
How to take
Tru Niagen® Pro?
[1] E.F. Fang, S. Lautrup, Y. Hou, T.G. Demarest, D.L. Croteau, M.P. Mattson, V.A. Bohr, NAD+ in Aging: Molecular Mechanisms and Translational Implications, Trends Mol Med. 23 (2017) 899–916. https://doi.org/10.1016/j.molmed.2017.08.001.
[2] L. Rajman, K. Chwalek, D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence, Cell Metab. 27 (2018) 529–547. https://doi.org/10.1016/j.cmet.2018.02.011.
[3] E. Verdin, NAD+ in aging, metabolism, and neurodegeneration, Science. 350 (2015) 1208–1213. https://doi.org/10.1126/science.aac4854.
[4] J. Yoshino, J.A. Baur, S. Imai, NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR, Cell Metab. 27 (2017) 513–528. https://doi.org/10.1016/j.cmet.2017.11.002.
[5] H. Massudi, R. Grant, N. Braidy, J. Guest, B. Farnsworth, G.J. Guillemin, Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue, Plos One. 7 (2012) e42357. https://doi.org/10.1371/journal.pone.0042357.
[6] S.A.J. Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud, C. Brenner, Nicotinamide riboside is uniquely and orally bioavailable in mice and humans, Nat Commun. 7 (2016) 12948. https://doi.org/10.1038/ncomms12948.
[7] S.E. Airhart, L.M. Shireman, L.J. Risler, G.D. Anderson, G.A.N. Gowda, D. Raftery, R. Tian, D.D. Shen, K.D. O’Brien, An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers, Plos One. 12 (2017) e0186459. https://doi.org/10.1371/journal.pone.0186459.
[8] C.R. Martens, B.A. Denman, M.R. Mazzo, M.L. Armstrong, N. Reisdorph, M.B. McQueen, M. Chonchol, D.R. Seals, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults, Nat Commun. 9 (2018) 1286. https://doi.org/10.1038/s41467-018-03421-7.
[9] D. Conze, C. Brenner, C.L. Kruger, Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults, Sci Rep-Uk. 9 (2019) 9772. https://doi.org/10.1038/s41598-019-46120-z.
[10] Y.S. Elhassan, K. Kluckova, R.S. Fletcher, M.S. Schmidt, A. Garten, C.L. Doig, D.M. Cartwright, L. Oakey, C.V. Burley, N. Jenkinson, M. Wilson, S.J.E. Lucas, I. Akerman, A. Seabright, Y.-C. Lai, D.A. Tennant, P. Nightingale, G.A. Wallis, K.N. Manolopoulos, C. Brenner, A. Philp, G.G. Lavery, Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures, Cell Reports. 28 (2019) 1717-1728.e6. https://doi.org/10.1016/j.celrep.2019.07.043.
[11] B. Zhou, D.D. Wang, Y. Qiu, S. Airhart, Y. Liu, A. Stempien-Otero, K.D. O’Brien, R. Tian., Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure, J Clin Invest. 130 (2020) 6054–6063. https://doi.org/10.1172/jci138538.
[12] C. Zhang, E. Bjornson, M. Arif, A. Tebani, A. Lovric, R. Benfeitas, M. Ozcan, K. Juszczak, W. Kim, J.T. Kim, G. Bidkhori, M. Stahlman, P.O. Bergh, M. Adiels, H. Turkez, M.R. Taskinen, J. Bosley, H.U. Marschall, J. Nielsen, M. Uhlen, J. Boren, A. Mardinoglu, The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease, Mol Syst Biol. 16 (2020) e9495. https://doi.org/10.15252/msb.209495.
[13] C.M.E. Remie, K.H.M. Roumans, M.P.B. Moonen, N.J. Connell, B. Havekes, J. Mevenkamp, L. Lindeboom, V.H.W. de Wit, T. van de Weijer, S.A.B.M. Aarts, E. Lutgens, B.V. Schomakers, H.L. Elfrink, R. Zapata-Pérez, R.H. Houtkooper, J. Auwerx, J. Hoeks, V.B. Schrauwen-Hinderling, E. Phielix, P. Schrauwen, Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans, Am J Clin Nutrition. 112 (2020) 413–426. https://doi.org/10.1093/ajcn/nqaa072.
[14] O.L. Dollerup, B. Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stødkilde-Jørgensen, N. Møller, C. Brenner, J.T. Treebak, N. Jessen, A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects, Am J Clin Nutrition. 108 (2018) 343–353. https://doi.org/10.1093/ajcn/nqy132.
[15] C. Canto, R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, P. Cettour-Rose, K. Gademann, C. Rinsch, K. Schoonjans, A.A. Sauve, J. Auwerx, The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity, Cell Metab. 15 (2012) 838–47. https://doi.org/10.1016/j.cmet.2012.04.022.
[16] H. Zhang, D. Ryu, Y. Wu, K. Gariani, X. Wang, P. Luan, D. D’Amico, E.R. Ropelle, M.P. Lutolf, R. Aebersold, K. Schoonjans, K.J. Menzies, J. Auwerx, NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice, Science. 352 (2016) 1436–1443. https://doi.org/10.1126/science.aaf2693.
[17] K. Gariani, K.J. Menzies, D. Ryu, C.J. Wegner, X. Wang, E.R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y.K. Park, A. Piersigilli, T.X. Pham, Y. Yang, C.S. Ku, S.I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A.A. Sauve, J.Y. Lee, J. Auwerx, Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice, Hepatology. 63 (2016) 1190–204. https://doi.org/10.1002/hep.28245.
[18] L. Mouchiroud, R.H. Houtkooper, N. Moullan, E. Katsyuba, D. Ryu, C. Cantó, A. Mottis, Y.-S. Jo, M. Viswanathan, K. Schoonjans, L. Guarente, J. Auwerx, The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling, Cell. 154 (2013) 430–441. https://doi.org/10.1016/j.cell.2013.06.016.
[19] S. Wang, T. Wan, M. Ye, Y. Qiu, L. Pei, R. Jiang, N. Pang, Y. Huang, B. Liang, W. Ling, X. Lin, Z. Zhang, L. Yang, Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway, Redox Biol. 17 (2018) 89–98. https://doi.org/10.1016/j.redox.2018.04.006.
What is
Tru Niagen® Pro?
What's in the bottle?
How to take
Tru Niagen® Pro?
Product line includes: Tru Niagen® Pro 300mg, Tru Niagen® Pro 500mg, and Tru Niagen® Stick Packs
What To Expect
A Safe, Evidence-Based Approach To Ongoing Cellular Health
[ 1 ] Fang, E.F., S. Lautrup, Y. Hou, T.G. Demarest, D.L. Croteau, M.P. Mattson, and V.A. Bohr, NAD(+) in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med, 2017. 23(10): p. 899-916. [ 2 ] Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD+-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547. [ 3 ] Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13. [ 4 ] Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528. [ 5 ] Massudi, H., R. Grant, N. Braidy, J. Guest, B. Farnsworth, and G.J. Guillemin, Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357. [ 6 ] Trammell, S.A., M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud, and C. Brenner, Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948. [ 7 ] Airhart, S.E., L.M. Shireman, L.J. Risler, G.D. Anderson, G.A. Nagana Gowda, D. Raftery, R. Tian, D.D. Shen, and K.D. O’Brien, An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459. [ 8 ] Martens, C.R., B.A. Denman, M.R. Mazzo, M.L. Armstrong, N. Reisdorph, M.B. McQueen, M. Chonchol, and D.R. Seals, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286. [ 9 ] Conze, D., C. Brenner, and C.L. Kruger, Safety and Metabolism of Long-term Administration of Niagen® (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep, 2019. 9(1): p. 9772. [ 10 ] Canto, C., R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, P. Cettour-Rose, K. Gademann, C. Rinsch, K. Schoonjans, A.A. Sauve, and J. Auwerx, The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47. [ 1 1 ] Zhang, H., D. Ryu, Y. Wu, K. Gariani, X. Wang, P. Luan, D. D’Amico, E.R. Ropelle, M.P. Lutolf, R. Aebersold, K. Schoonjans, K.J. Menzies, and J. Auwerx, NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 2016. 352(6292): p. 1436-43. [ 12 ] Gariani, K., K.J. Menzies, D. Ryu, C.J. Wegner, X. Wang, E.R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y.K. Park, A. Piersigilli, T.X. Pham, Y. Yang, C.S. Ku, S.I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A.A. Sauve, J.Y. Lee, and J. Auwerx, Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204. [ 13 ] Mouchiroud, L., R.H. Houtkooper, N. Moullan, E. Katsyuba, D. Ryu, C. Canto, A. Mottis, Y.S. Jo, M. Viswanathan, K. Schoonjans, L. Guarente, and J. Auwerx, The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell, 2013. 154(2): p. 430-41. [ 14 ] Wang, S., T. Wan, M. Ye, Y. Qiu, L. Pei, R. Jiang, N. Pang, Y. Huang, B. Liang, W. Ling, X. Lin, Z. Zhang, and L. Yang, Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98. [ 15 ] Dollerup, O.L., B. Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stodkilde-Jorgensen, N. Moller, C. Brenner, J.T. Treebak, and N. Jessen, A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.l